Jan Bogaerts
Jan BogaertsChair

Director, Methodology Direction, EORTC Headquarters,
Brussels, Belgium

Jan Bogaerts earned his degree in mathematics (1986) and his PhD in mathematics (1993) at the Free University of Brussels (Belgium). In 1988 he also earned a degree in management at the Free University in Brussels. He joined BMS in 1993 as statistician. Later, as Associate Director Statistics he worked on several drugs in oncology, including several FDA and EMEA submissions. In 2004 he joined the EORTC as statistician of the EORTC Breast Cancer Group. He now has the role of Methodology Director. He contributed to the development of RECIST and is on the RECIST Steering Committee. Another key role of his is statistician of the MINDACT trial EORTC 10041 – BIG 3-04 which will report the primary results in 2016. Current statistical interests include the use of and methodological issues around Progression Free Survival, alternative ways to use changes in tumour measurements as predictive markers, and the correct evaluation of the contribution of new markers to existing prognostic risk evaluation. He also has a high interest in closing the gap between clinical trials and day-to-day practice, and in increasing scientific learning from merging multiple data sources.

Saskia Litière
Saskia LitièreCo-Chair

Associate Head of Statistics Department, EORTC Headquarters
Brussels, Belgium

Saskia Litière obtained her degree of Applied Mathematics at the University of Ghent in 2001. In that same year she started her career as a statistician in the Center for Statistics (Censtat) at the Hasselt University. Over a period of nine years she was involved in the reorganization of the MSc in Applied Statistics program, she obtained the degree of MSc in Biostatistics, she worked as statistical consultant, she was involved in the teaching of several Bachelor and Master level courses in statistics and she successfully defended her PhD thesis on the topic of misspecification in generalized linear mixed models. In September 2010 she joined the EORTC statistics department, since 2017 as Associate Head of the Statistics Department. She has worked with the EORTC Breast Cancer Group and is currently the statistician of the EORTC Soft Tissue and Bone Sarcoma Group. She is also involved in the ongoing update of RECIST and is currently one of the course directors of the EORTC-ESMO-AACR Workshop on Methods in Clinical Cancer Research.

Xavier Paoletti
Xavier PaolettiCo-Chair

Professor of Biostatistics, Université de Versailles – St Quentin (UVSQ) & Institut Curie, St-Cloud, France

Xavier Paoletti is Professor of biostatistics at the University of Versailles St Quentin and at Curie Cancer Center, in Paris, France; he is also a member of the research INSERM STAMPM unit dedicated to the development of statistical methods for clinical trials integrating biomarkers. After a phd on early phase clinical trials under the supervision of John O’Quigley, Xavier had several positions at the EORTC, at the French NCI and in two leading cancer centers, Institut Curie and Gustave Roussy. His main interests are in the methods for dose finding trials, the designs of trials evaluating personalized medicine such as the SHIVA or Esmart trials and the validation of surrogate endpoints. He is the coordinator with Koji Oba of the GASTRIC collaboration for performing meta-analyses in gastric cancers and with Dr Ros Glasspool of the gynecology cancer intergroup meta-analysis committee.

David Cairns
David CairnsSpeaker

Associate Professor of Statistics in Late Phase Cancer Clinical Trials
CTRU, Leeds University, Leeds, United Kingdom

David is Associate Professor of Statistics in Late Phase Cancer Clinical Trials and the Director of Late Phase Trials in the Cancer Division at CTRU. David joined CTRU as a Principal Statistician working across the Cancer Division and Comprehensive Health Research Division in July 2013.

David was previously Senior Research Fellow in Biostatistics at the Leeds Institute of Cancer and Pathology where he worked in high-dimensional data analysis related to a number of translational projects in genetics, proteomics and biomarker discovery and validation. David was the recipient of an MRC Career Development Award in Biostatistics to undertake research in ‘Novel statistical methods for the design and analysis of proteomic experiments for biomarker discovery’.

Corneel Coens
Corneel CoensSpeaker

Lead Statistician, Statistics Department, EORTC Headquarters, Brussels, Belgium

Corneel Coens is currently working as a statistician at the EORTC Headquarters (Brussels, Belgium). As part of his tasks for the EORTC Quality of Life Department, he is involved in various aspects of Quality of Life in many oncological clinical trials ranging from instrument validation to design, analysis and reporting of QoL endpoints. He is also the designated study statistician for the EORTC Gyneacological Cancer Group since 2001. He is a regular contributor for various EORTC educational courses and is course director for the Joint FECS/AACR/ASCO Workshop “Methods in Clinical Cancer Research”.

Laurence Collette
Laurence ColletteSpeaker

Former Head of Statistics Department, Head of IDMC Unit
EORTC Headquarters, Brussels, Belgium

Dr Laurence Collette PhD, MSc is former head of the statistics department of the EORTC Headquarter that she joined in 1995. She obtained a Master in Mathematics from Catholic University of Louvain-la-Neuve (BE) and a Masters in Biostatistics from Hasselt University (BE) and a PhD from Rotterdam University (NL) on surrogate endpoints in prostate cancer. Her research interests include biomarker-based treatment selection, interim trial monitoring and innovative trial designs, with a focus on urological malignancies and on non-drug interventions (irradiation, surgery), including quality assurance. To date, she co-authored over 150 peer-reviewed articles in cancer clinical trials and related methods. She also lead the EORTC Data Sharing Policy and the EORTC Publication and Disclosure Policy. She was member of a number of independent data monitoring committees and coordinated the activities of the IDMC for the EORTC. She organised methodology courses to train non-statisticians to the methodology of cancer research.

Marta Fiocco
Marta FioccoSpeaker

Associate Professor, Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands

Marta Fiocco got her PhD in Mathematical Statistics from Leiden University (The Netherlands) in 1997. She works as Associate Professor at the Mathematical Institute of Leiden University and at the Medical Statistics, Department of Biomedical Data Sciences of Leiden University Medical Centre. She is resident Associate Professor at Dutch Children Oncology Group and Prinses Máxima Centrum voor kinderoncologie (Utrecht), where she is responsible for the statistical aspects of clinical studies in the field of children oncology in the Netherlands. She is the group leader of Data Analysis and Survival in Personalized Oncology (DASPO https://sites.google.com/view/daspo). The major task of DASPO is to perform high-quality quantitative research on survival analysis and related topics in the field of personalized oncology. The group is active in the development of new methodologies for inference on the effectiveness of therapeutic regimens in fighting cancer. The group is also interested in the correct application and adaptation of existing statistical techniques to an oncology setting. Webpage: https://www.universiteitleiden.nl/en/staffmembers/marta-fiocco#tab-1

Catherine Fortpied
Catherine FortpiedSpeaker

Lead Statistician, Statistics Department, EORTC Headquarters, Brussels, Belgium

Catherine Fortpied has a Master degree in Statistics from the University of Lisbon in Portugal (1997). She worked as statistician in the pharmaceutical industry, from 1998 to 2008, in the allergy-immunology and central nervous system therapeutic areas. She joined the EORTC in 2008, as senior statistician, giving support for the design and analysis of clinical trials of the Lymphoma and Head and Neck Cancer Groups.

Michal Kicinski
Michal KicinskiSpeaker

Statistician, Statistics Department, EORTC Headquarters,
Brussels, Belgium

Michal Kicinski earned his Master of Science in Statistics, Specialization biostatistics, with great distinction from KU Leuven in 2011, Belgium, and his PhD in Science from Hasselt University, Belgium in 2015. As a researcher at Hasselt University, Michal conducted studies in the field of epidemiology, worked as a statistical consultant, performed research on methods to detect publication in meta-analysis, and investigated the size of publication bias in published meta-analyses. Michal joined the EORTC after obtaining his PhD. As a fellow, he worked on studies assessing the long-term outcomes among survivors of Hodgkin lymphoma and childhood ALL, studies comparing outcomes of patients treated in and outside clinical trials, a phase III melanoma trial comparing adjuvant pembrolizumab with placebo, and analyses of prognostic and predictive factors in childhood ALL and adult AML. Currently, Michal works as a biostatistician for the EORTC Leukemia, Children Leukemia, and Melanoma groups. In addition, he is involved in a study on methods to deal with crossover in analysis of overall survival and a study of methods to compare treatments when the hazards are non-proportional.

Catherine Legrand
Catherine LegrandSpeaker

Professor at the Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA), Université Catholique de Louvain (UCL),
Louvain-la-Neuve, Belgium

Catherine Legrand obtained a Master Degree in Mathematics from the Université Libre de Bruxelles (ULB) in 1998. She worked for 7 years at the European Organization for Research and Treatment of Cancer (EORTC) became the primary statistician of the EORTC Lung Cancer Group. She was also a member of the Treatment Outcome Research Group, the Elderly Task Force, and coordinator of the EORTC Independent Data Monitoring Committee. In parallel, she completed a PhD in 2005 at the Center for Statistics, Hasselt University, in the field of survival analysis (frailty models). Early 2006, she started working as biometrician at Merck Sharp & Dohme (MSD) where she was involved in the design and analysis of clinical trials in respiratory diseases. Since September 2007, she Professor at the Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA-LIDAM) of the Université catholique de Louvain (UCLouvain). Her area of research includes survival data analysis and design of clinical trials. Along with these professional experiences, she co-authored more than 80 papers in peer-reviewed clinical and statistical journals and is also Associate Editor for Biometrics.

Steven MacLennan
Steven MacLennanSpeaker

Research Fellow,Academic Urology Unit, the University of Aberdeen, Scotland, United Kingdom

My research involves clinical trials, as well systematically reviewing, critically appraising and synthesising intervention effectiveness data, and incorporating these forms of evidence in clinical practice guideline (CPG) recommendations using transparent evidence-to-decision methods. I also apply mixed methods in developing core outcome sets, and in consensus projects to assist CPG panels to give interim guidance in the face of no evidence, low quality evidence or conflicting evidence. Another arm of my research is directed toward addressing evidence gaps whereby interventions underpinned by high quality evidence and strong recommendations in CPGs are not routinely followed – this again requires a mixed methods approach to investigate practice patterns, barriers and facilitators to practice, and developing knowledge transfer interventions. I am a member of the European Association of Urology’s (EAU) methodology committee which oversees and delivers the EAU’s systematic review and CPG development training programmes, and a founding member of the EAU’s IMAGINE group, which aims to tackle evidence-to-practice gaps in urology.

Murielle Mauer
Murielle MauerSpeaker

Lead Statistician, Statistics Department, EORTC Headquarters, Brussels, Belgium

Murielle Mauer has a PhD in Pure Mathematics. She was Assistant at the Faculty of Science at the University of Liège from 1995 to 2001 and researcher in the Department of Biostatistics and Data Processing at the University Hospital of Liège from 2001 to 2003. She got a Master degree in Biostatistics at Limburgs Universitair Centrum in 2003. She got practical experience of the design, conduct and analysis of clinical trials in Bristol-Myers Squibb pharmaceutical company from 2003 to 2006. At EORTC, she worked as a research fellow in the Quality of Life Unit. Since 2007, she is the Biostatistician in charge of providing statistical support to the EORTC Gastro-intestinal Tract Cancer Group and to the EORTC Elderly Task Force.

Stefan Michiels
Stefan MichielsSpeaker

Director Oncostat Team CESP, INSERM U1018, Department of Biostatistics and Epidemiology, Institut Gustave Roussy,
Villejuif, France

Stefan Michiels is Director of the Oncostat team, INSERM U1018, University Paris-Sud, and Head of Methodology in the Department of Biostatistics and Epidemiology at Gustave Roussy, Villejuif, France. His areas of expertise are statistical analysis of biomarker and genomic data, prognostic models, clinical trials, Independent Data Monitoring Committees and meta-analyses in oncology. He holds a PhD in Biostatistics from the School of Public Health at the Paris XI University and Master Degrees in Statistics and in Applied Mathematics from the University of Leuven. His previous positions include the Université Libre de Bruxelles-Institut Jules Bordet (FNRS researcher), the National Cancer Institute (France) and the University of Leuven (Belgium). He has authored above 100 peer-reviewed publications in journals such as Lancet, JAMA, Lancet Oncology, NEJM, JCO, Journal of Clinical Epidemiology, Statistics in Medicine, Bioinformatics and Statistical Methods in Medical Research. He is member of the editorial board of Journal of the National Cancer Institute, Annals of Oncology, Cancer Prevention Research, the Breast and does regular statistical reviews for The Lancet journals.

Anouk Neven
Anouk NevenSpeaker

Biostatistician, Statistics Department, EORTC Headquarters, Brussels, Belgium

Anouk Neven holds a Master degree in Mathematics that she obtained at the Université Libre de Bruxelles (2012). After receiving her master’s degree, she carried out a year of research in the field of statistics with applications in finance at the University of Luxembourg. From 2013 to 2017, she worked as a teacher in mathematics and statistics in a secondary school in Luxembourg. She joined the EORTC in 2017, as a fellow in biostatistics, where she was involved in the designs of clinical trials. In March 2018, she became a full time biostatistician at EORTC Headquarters Statistics Department.

Coralie Poncet
Coralie PoncetSpeaker

Senior Statistician, Statistics Department, EORTC Headquarters, Brussels, Belgium

Coralie Poncet obtained Master’s degree in Engineering in agronomics and life sciences from AgroParisTech in France in 2007. She also earned a degree in quantitative epidemiology and statistical methodology. She worked as a statistician in the pharmaceutical industry from 2008 to 2016. She was involved in pharmaco-epidemiological studies and supported HTA submissions, mostly in rheumatology and immuno-oncology therapeutic areas. She joined the EORTC in 2017, as a senior statistician, providing support for the design and analysis of clinical trials of the breast Cancer Group.

Matthew Sydes
Matthew SydesSpeaker

Senior Scientist and Statistician, MRC Clinical Trials Unit at UCL, London, United Kingdom

Matt Sydes, Reader in Clinical Trials at MRC Clinical Trials Unit at UCL, London. Matt is a statistician and trialist leading teams conducting late stage clinical trials and associated methodology. Notable trials include STAMPEDE, a large randomised clinical trial successfully putting novel multi-arm multi-stage methods into practice and EURAMOS-1, the largest RCT conducted in osteosarcoma, thanks to an extensive international collaboration. Matt chairs the Unit’s Protocol Review Committee, led the development of the template protocol for clinical trials, and is part of the Standard Operating Procedure Committee. Externally, he is a member of the NCRI Prostate Cancer Clinical Studies Group (CSG) and sits on the Bone Subgroup of the NCRI Sarcoma CSG. He completed 5 years on Cancer Research UK’s clinical trials funding body, CTAAC, and seven years on a Research Ethics Committee. Matt was part of the DAMOCLES project which set standards for (Independent) Data Monitoring Committees and led to the widespread use of charters for trial committees and has attended >100 IDMC meetings.